These relationships, shown in the figure, are summarized here and here. Director of PHD Program in Population Health Sciences. Bill Hanage is an associate professor of epidemiology at the Harvard TH Chan School of Public Health. With many collaborators, we were heavily involved in analyzing data and providing advice to public health authorities during the 2009 influenza pandemic. A longstanding collaboration with Caroline Colijn, Christophe Fraser, Bill Hanage and Ted Cohen continues to explore alternative explanations for the phenomenon. Seasonal influenza: mechanisms and forecasting. Chan School of Public Health’s Nancy Krieger discusses the impact that COVID-19 is having on communities of color. Another problem in the population biology of pneumococci of longstanding interest is antimicrobial resistance. D.Phil., 1995, Zoology, University of Oxford, Photo Credit: Stephanie Mitchell/Harvard University News Office, Copyright © 2020 The President and Fellows of Harvard College, Harvard T.H. Chan School of Public Health and director of the Center for Communicable Disease Dynamics. Currently we are working with several groups to model the impact of pneumococcal vaccine programs. We have developed and applied an improved regression framework to estimate the mortality burden from seasonal influenza, including multiple listed causes of disease. Seasonal influenza: burden of disease estimation. I am Professor of Epidemiology with primary appointment in the Department of Epidemiology and a joint appointment in the Department of Immunology and Infectious Diseases, where my wet lab is located. In an article entitled You’re Likely to Get the Coronavirus , the Atlantic explains how the coronavirus is particularly dangerous because it may cause cause no symptoms at all in many carriers of the infection. Much of my work focuses on the bacterial pathogen Streptococcus pneumoniae (pneumococcus) which colonizes the nasopharynx of 30-100% of children worldwide, and causes otitis media, septicemia, pneumonia and meningitis in a small fraction, but a large number of them, with an estimated 800,000+ child deaths a year attributed to pneumococcal disease. On October 2014 the White House announced a 1-year funding pause on such experiments, pending a risk-benefit assessment. We are currently undertaking sequencing of a comparably-sized collection of pneumococci from Navajo and White Mountain Apache populations in the Southwestern US, in collaboration with Kate O’Brien of the Johns Hopkins Bloomberg School of Public Health. Attention was refocused on laboratory safety by laboratory mishaps in spring-summer, 2014 at the NIH and CDC, which I argued in a New York Times op-ed should stimulate careful risk assessment before such work proceeds. Additionally, collaborating with colleagues at the CDC’s Active Bacterial Core surveillance, we have assessed trends in resistance at the national level and partitioned these into effects of changing serotype distribution and changing resistance within serotype, both before and since the introduction of conjugate vaccines. Projects have included collaboration on with SPARC, a visionary project led by Jonathan Finkelstein and Grace Lee with collaborators Bill Hanage and Steve Pelton , that provided a nearly unique view of the epidemiology of pneumococcal carriage through the introduction of two vaccines, PCV7 and PCV13. Projects include: Science Policy: Creating Potential Pandemic Pathogens (PPP) in the Laboratory. Antimicrobial resistance. This suggested the possibility of effective control measures, despite the difficulties inherent in controlling an illness in which transmission could precede symptoms. Caroline Buckee, associate professor of epidemiology, Department of Epidemiology, Harvard T.H. Early work focused on measuring the in vivo fitness cost of resistance and documenting the cotransfer of capsular and resistance loci in the lab. The seasonality of infectious diseases is one of the oldest observations in medicine, yet the mechanisms underlying seasonality are poorly understood. Associate Professor of … Chan School of Public Health and Brigham and Women’s Hospital. Chan School of Public Health, and Marc Lipsitch, a professor of epidemiology there, teamed up recently to offer news outlets advice on covering the outbreak. inference of transmission from pathogen sequence data, pathogen genetic distances in transmission networks, limitations and risks of such experiments, ethical aspects and alternative approaches, barriers to achieving the experiments’ claimed public health goals, White House announced a 1-year funding pause, calculations that should enter such an assessment, Cambridge Center for the Study of Existential Risk, Academic Departments, Divisions and Centers, MRSA: We have applied population genetic approaches to show that patient transfer between hospitals, MCMC approaches to analyze household data to assess time-varying infectiousness with SARS (with, Use of temporal variation in risk factors for infectious disease to infer transmission networks. Chan School of Public Health, Master of Science in Computational Biology and Quantitative Genetics- 80 Credits, Master of Science – 42.5 Credit (Academic Year), Master of Science – 42.5 credit (Summer Only), Environmental and Occupational Epidemiology, Genetic Epidemiology and Statistical Genetics, Reproductive, Perinatal, and Pediatric Epidemiology, Department of Epidemiology Coronavirus (COVID-19) Updates and News, Assistant/Associate Professor of Radiation Epidemiology. With Gabriela Gomes we have been exploring the consequences of modeling vaccines as shifting the dose-response curve to the right. On questions of countermeasure optimization, we derived conditions for the predispensing of antivirals to high-risk persons to be life-saving and estimated the impact of targeting high-risk persons for vaccination. website. Academic Departments, Divisions and Centers. p: (617) 432-2441. An exciting collaboration led by Andrew Wargo, including Gabriela and Gael Kurath, examines this question experimentally using two vaccines against diseases of salmon. We have also been interested more broadly in the genomic diversity of pneumococci, and in particular in the diversity of protein antigens, some of which are targets of antibody elicited by the pneumococcus, and others of which are likely targets of CD4+ Th17 responses. firstname.lastname@example.org. Dr. Harvey Risch, … In progress are further explorations of the ethical dimensions with Nick Evans. Lisa Berkman. Karen Huang’s master’s thesis estimated a ~20% increase in the reproductive number of pandemic flu when schools opened in fall, 2009. In the course of studying this question, we realized that our (and others’) earlier mathematical models of serotype coexistence had inadvertently created “coexistence for free” in models by innocuous-seeming mathematical assumptions that corresponded to no known biological mechanism. Director, Institute of Public Health, Charité – Universitätsmedizin Berlin Adjunct Professor of Epidemiology, Harvard Chan School of Public Health. Early on, we published articles with international collaborators on decision-making under uncertainty during the pandemic and on how to maintain surveillance when cases become uncountable. Müge Çevik, clinical lecturer in infectious diseases and medical virology, Infection and Global Health Division, School of Medicine, University of St Andrews. Their essay, “How to Report on the COVID-19 Outbreak Responsibly,” appears on a Scientific American blog. He is additionally an Assistant Professor in Immunology and Infectious Diseases at HSPH and Associate Medical Director in Clinical Microbiology (molecular diagnostics) in the Department of … Dr. Harvey Risch, a professor of epidemiology at the Yale School of Public Health and Yale School of Medicine joined Fox News host Laura Ingraham Wednesday. Development of new methods for infectious disease data analysis. epidemiology, former Research Fellow at Harvard Medical School. Jose Zubizarreta. Scale up “the production of … Jessica Jacobs’ dissertation estimated that ~13% of meningococcal disease in the US was flu-attributable. Duration-reducing immunity, although not specific to individual serotypes, has a disproportionate impact on the long-duration (high fitness) serotypes because it reduces their duration of carriage proportionally more. Sarah Cobey took on the challenge of trying to explain serotype coexistence. According to Harvard epidemiology professor Marc Lipsitch, this contributes to his prediction that coronavirus “will ultimately not be containable.” “Lipsitch predicts that, within the coming year, some 40 to 70 percent of people around the world will be infected … I also served on “Team B” for the United States CDC, providing external advice during the pandemic. Emily Harrison is a Postdoctoral Fellow in Epidemiology and the History of Science at Harvard University. Other work has focused on the risk that multiple introductions could compromise attempts to contain a pandemic at the sources, and on the potential for drug resistance following massive antiviral use in a pandemic. But I never made it past the first page. Recent efforts have included an outline of the calculations that should enter such an assessment (with Tom Inglesby) and pieces for more general readers including a debate in Nature Reviews Microbiology and an opinion piece Scientific American. We supplemented these experimental observations with epidemiologic analysis that showed evidence of modest serotype-specific immunity to colonization (collaboration with Ron Dagan‘s group), and acquisition of duration-reducing immunity to all serotypes in the first years of life (collaboration with Anthony Scott’s group including Osman Abdullahi).
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